Abnormal synapses, recombination, and impaired double-strand break repair in a man with nonobstructive azoospermia
نویسندگان
چکیده
منابع مشابه
Double-strand break repair and homologous recombination in Schizosaccharomyces pombe.
The study of double-strand break repair and homologous recombination in Saccharomyces cerevisiae meiosis has provided important information about the mechanisms involved. However, it has become clear that the resulting recombination models are only partially applicable to repair in mitotic cells, where crossover formation is suppressed. In recent years our understanding of double-strand break r...
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Homologous recombination (HR) provides an important mechanism to repair both accidental and programmed DNA double-strand breaks (DSBs) during mitosis and meiosis. Defects in HR are associated with mutagenesis and predispose to cancer, highlighting the importance of this pathway for preserving genome integrity (Moynahan and Jasin, 2010). HR is active in the S and G2 phases of the cell cycle wher...
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DNA double-strand breaks (DSBs) are the most dangerous form of DNA damage and can lead to death, mutation, or malignant transformation. Mammalian cells use three major pathways to repair DSBs: homologous recombination (HR), classical nonhomologous end joining (C-NHEJ), and alternative end joining (A-NHEJ). Cells choose among the pathways by interactions of the pathways with CtIP and 53BP1. HR i...
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ownloade C regulates a myriad of genes controlling cell proliferation, metabolism, differentiation, and apoptosis. lso controls the expression of DNA double-strand break (DSB) repair genes and therefore may be a ial target for anticancer therapy to sensitize cancer cells to DNA damage or prevent genetic instability. report, we studied whether MYC binds to DSB repair gene promoters and modulates...
متن کاملDNA double-strand break repair
The integrity of genomic DNA is crucial for its function. And yet, DNA in living cells is inherently unstable. It is subject to mechanical stress and to many types of chemical modification that may lead to breaks in one or both strands of the double helix. Within the cell, reactive oxygen species generated by normal respiratory metabolism can cause double-strand breaks, as can stalled DNA repli...
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ژورنال
عنوان ژورنال: Asian Journal of Andrology
سال: 2018
ISSN: 1008-682X
DOI: 10.4103/aja.aja_69_17